What Are Bioactives?


Bioactives are natural compounds that are biologically active in the body. Bioactives from medicinal plants have the potential to improve health in ways that go beyond what ordinary vitamin, mineral, and herbal supplements can offer. This is borne out in an ever-growing body of research. Independent scientists around the world have confirmed that a substantial number of bioactives provide verifiable health benefits without harmful side effects.

Anti-inflammatory bioactives from medicinal plants

  • Natural products have long been a thriving source for the discovery of new drugs because of their chemical diversity. With increased use of herbal remedies, traditionally used medicinal plants are receiving increased attention from scientific and pharmaceutical communities. The newer work on medicinal plants is mostly the rediscovery of traditional effects at cellular and molecular levels. Development of standardized, safe and effective herbal formulations as multi-target therapeutics and prophylaxis could be a tenable approach for the future. Hundreds of plant metabolites are reported to have many pharmacological activities although most of these reports are of academic interest and very few find entry at clinical trials. Compilation of the information would help promote wider acceptance and use of these plant based drugs in main stream of medicine.

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·         Blueberry Iridoids Supports healthy inflammatory response. The highest antioxidant capacity of all fresh fruit: Blue Berries, being very rich in anti oxidants like Anthocyanin, vitamin C, B complex, vitamin E, vitamin A, copper (a very effective immune builder and anti-bacterial), selenium, zinc, iron (promotes immunity by raising hemoglobin and oxygen concentration in blood) etc. boost up your immune system and prevent infections. Once your immunity is strong, you will not catch colds, fever, pox and all such nasty viral and bacterial communicable diseases.

·         Blue Berries bring you the brightest ray of hope, for they are laden with anti oxidants and rank number 1 in the world of anti oxidants. This is mainly due to presence of Anthocyanin, a pigment responsible for the blue color of the blue berries. The abundance of vitamin-C is also a big factor for this as well.

·         Aid in reducing Belly Fat:

·         A new University of Michigan Cardiovascular Center study suggests that blueberries may help reduce belly fat and risk factors for cardiovascular disease and metabolic syndrome.

·         Helps promote urinary tract health: The building of colonies of certain bacteria like b-coli along the lining of the inner walls of urinary tract is responsible for this infection, resulting in inflammation, burning sensation during in passage of urine and other complications. Here, Blue Berries can be surprisingly beneficial. It has a compound formed of big polymer like heavy molecules which inhibits the growth of such bacteria. It also has some anti biotic properties which adds to this effect. These heavy and big molecules almost wash-off these bacteria along the tract, thereby preventing the infection.

·         Been proved to preserve vision: Blueberry extract, high in compounds called anthocyanosides, has been found in clinical studies to slow down visual loss. They can prevent or delay all age related ocular problems like macular degeneration, cataract, myopia and hypermetropia, dryness and infections, particularly those pertaining to retina, due to their anti-oxidant properties. Blue Berries contain a special group of anti oxidants called Carotenoids (lutein, zeaxanthin etc.), Flavonoids (like rutin, resveritrol, quercetin etc.), in addition to others such as vitamin C, vitamin E and vitamin A, selenium, zinc and phosphorus, which are very beneficial and essential for the ocular health. Data reported in a study published in the Archives of Ophthalmology indicates that eating 3 or more servings of fruit per day may lower your risk of age-related macular degeneration (ARMD), the primary cause of vision loss in older adults, by 36%, compared to persons who consume less than 1.5 servings of fruit daily.

·         Cancer: Blue Berries can prove to be bliss for the cancer patients, for they contain certain compounds like Pterostilbene (excellent remedy for colon and liver cancer) and Ellagic Acid which, in harmony with Anthocyanin and other anti oxidants like vitamin-C and copper, can do miracles to prevent and cure cancer. Laboratory studies published in the Journal of Agricultural and Food Chemistry show that phenolic compounds in blueberries can inhibit colon cancer cell proliferation and induce apoptosis (programmed cell death). A significant 34% reduction in ovarian cancer risk was also seen in women with the highest intake of the flavone luteolin (found in citrus).

·         Other benefits & facts: They keep you fresh, active, fit, sharp, close to nature and in a good mood, as they are very good anti depressants. You also need not spend a lot on medicines, neither are there any side effects. Remember, the deeper the color of the Blue Berries, the more they are rich in anti oxidants and other medicinal values.

·         Morinda Citrifolia benefits known as Noni fruit

·          Noni Iridoids, DNA protective, Supports healthy inflammatory response; Protects the cells, Promotes joint flexibility and mobility, Cholesterol-friendly, Supports healthy blood glucose levels.

·         Recently discovered that it stimulates two major hormones called serotonin and melatonin. The pineal gland controls the five other glands below it which are the thyroid which produces thyroxin to energize our cells, the thymus which protects you against infections and cancer, the pancreas which is involved with blood sugar and secreting the hormone insulin, the adrenal gland which responds every time you are under stress; and the first gland is the male and female sex organs and their hormones. Therefore restoring the sixth gland, the pineal gland, will have an impact on all those other glands and their functions in the body. When the pineal gland is at its peak performance, it turns a golden color and emits a black juice as well as golden oil.  That black juice would be the melanin color of the organs and every other area of the body, which has a pigment.

·         It happens that Noni juice mimics the secretion coming from the pineal gland, and in fact acts as a precursor to it, building it up and allowing it to function fully. Noni juice has a black color, very similar to the melanin that gives color or pigment to each one of our organs. Every place our body contains this pigment will be affected by Noni juice.

  • DR. SCOTT GERSON, M.D.
  • http://www.consumerhealth.org/articles/display.cfm?ID=19990303205600
  • Dr. Gerson has practiced medicine in Manhattan for the last 15 years. He is uniquely educated, having received his M.D. from Mount Sinai Medical School in New York, and his doctorate in ayurvedic medicine in India. He is currently teaching our new medical doctors at some of the most prestigious medical schools in America about alternative approaches in medicine. Several months ago, he addressed the United Nations on “the state of herbs in the world today”.
  • Several years ago, I was researching material for a book on the medicinal plants of India, and became interested in a family of plants known as Rubiaceae. Of particular interest was a plant known in Sanskrit as ach which was attributed special properties by ancient physicians. The fruit of this ach plant or Morinda citrafolia has a rich history in India where it has been used for tens of centuries in the system of medicine known as ayurveda. This holistic medical tradition was established in the north western part of India by a people called aryans who were reputed to be a rather cosmic civilization. Morinda citrifolia was especially esteemed by the ancient aryan physicians because it protected the skin from becoming dry and cracked from the sun. My investigation of the published scientific literature on Morinda citrifolia yielded more than 100 articles pertaining to this medicinal plant. I soon discovered that the original home of the plant was not India at all, but rather Polynesia, Micronesia and the Hawaiian Islands where it is known as noni.
  • I first investigated what was known about the compounds in the noni fruit. Not surprisingly I found that several important active constituents were already identified which had beneficial effects in human physiology. Among the most intriguing were the carotenoids, bioflavonoids and anthraquinones as well as several other unknown substances which according to their chemical structures appeared to be accessory activating factors.
  • At this point, I decided to take noni as a medicine on a regular basis myself. I had taken this direct experiential approach to learning about a plant medicine many times, as I had been taught to do in my training as an ayurvedic physician. It was late autumn, and although I was healthy, I was all too familiar with the pattern my physiology follows every year around this time. It always began with feelings of increasing stress, then bothersome skin eruptions, fatigue, mental irritability, bloating, constipation, and finally inevitably an upper respiratory infection, and it happened the same way every year. I reasoned that noni juice might confer some protective action against disease through its significant anti-oxidant components. In the past, I had consumed medicinal preparations hundreds of times with many of these same constituents without any appreciable effects. As it turned out, there was a marked difference in my health that autumn. I was distinctly more alert, more energetic, more balanced, my skin was glowing more than I could ever recall and my digestion was improved immeasurably. I attributed the benefits of noni to the interaction of the known components with the hitherto unknown components, which perhaps work synergistically with all the other nutrients.
  • The second part of my research is known as ethnobotony, where we seek out physicians or native healers who may have extensive experience in using a particular medicinal herb, and ask them what they use it for, how they prepare it, how successful it is and obtain direct information about its medical usefulness from people who have used it over many many years. The third aspect of my research process involves a thorough search of the current scientific and medical literature to determine whether any of the constituents of the plant in question are known to possess biological activity that may help shed some light on its effectiveness for the treatment of a certain disease or diseases.
  • With regard to Morinda Citrifolia, an interesting thing started to happen the more my research progressed. It seemed that the list of ailments for which noni was used medically just grew and grew longer than almost any other medicinal plant that I have ever encountered. I was initially overwhelmed at how many medical indications this single plant has had in the Pacific Islands and south east Asian literature.
  • A few of the medicinal uses are for digestive problems such as diarrhea, intestinal worms, nausea, food poisoning; respiratory problems such as congestive cough, dry cough, tuberculosis, cholera, infant chest colds and sore throat; cardiovascular problems, hypertension; inflammatory conditions such as arthritis, abscesses, mastitis, gout and other inflammatory joint conditions. It is a noted analgesic or pain reliever. One of the most common uses of noni has been in the area of skin conditions, being utilized for wounds, ulcers, abscesses, ring worm, boils, cellulitis, swellings, scalp conditions and sores. It has been used in the treatment of tumours and broken bones, jaundice and other forms of liver disease. It has been used to treat asthma and dysentery, hypercholesterolemia, menstrual cramps, gastric ulcers and diabetes.
  • Faced with such a diverse list of physiologically distinct conditions, the conventionally oriented physician might be tempted to completely dismiss these reports as unsubstantiated folk tales. We are conditioned to believe that any important medicinal substance should have one or at most two applications. How could one plant be used to treat so many pathological conditions?
  • To answer these questions, it was time to turn to the scientific research involving Morinda citrafolia. Research at the University of Hawaii’s Biomedical Sciences Department showed that extracts of noni contained a naturally occurring component which activates serotonin receptors in the brain and throughout the body. Serotonin is a neuroendocrine compound which along with its receptors is found in high levels in the brain, the blood platelets and the lining of the digestive tract. It is well established that serotonin is an important brain neurotransmitter, and plays a significant role in temperature regulation, sleep, hunger and sexual behaviour. Serotonin deficiency has been implicated in a number of pathological conditions including migraine headaches, obesity, depression and Alzheimer’s disease. Modern pharmaceutical medicine has had some success with the use of serotonin analogues in the treatment of certain diseases. I am sure many of you are familiar with the drug Prozac which is used to treat depression; another is used to treat acute migraine headaches. Both of these synthetic drugs specifically target and bind to serotonin receptors. The problem with both of these substances and with all synthetically manufactured pharmaceuticals which isolate one active ingredient is the great incidents of adverse side effects. Natural products like Morinda citrafolia in its unprocessed complete form do not generally have adverse effects. The presence of a wide range of other naturally occurring substances which are present in some way regulates and modifies its effects.
  • Research at the University of Metz in France, demonstrated the central analgesic activity of noni to alleviate pain of many types. Moderate doses of noni was measured to be about 75% as effective as an equivalent dose of morphine sulfate.
  • Since 1961, we have known that various parts of the Morinda citrafolia tree contains several different varieties of bitter plant compounds known as anthraquinones. Plants containing anthraquinones have literally been used for millennia due to their medicinal properties. Most noted are significant antiseptic (antibacterial) effect to disease causing bacteria in the intestinal tract. This compound is especially toxic to the pathogens Shigela and Salmonella. Anthraquinones are also particularly effective against many forms of Staphylococcus, a major cause of many skin infections which sometimes infect the valves of the heart. Furthermore anthraquinones in noni prompt the digestive secretions of the stomach and small intestines, stimulate bile flow and promote the activity of the entire digestive process. However, it is the activity of one specific anthraquinone, damnacanthal which has been shown in vitro to actually reverse cancer cell proliferation at the gene level. The research has demonstrated that one isolated component found in noni fruit turned off the signal for tumour cells to proliferate. The study was reported in 1993 from a very reputable laboratory in Kao University in Yokohama, Japan.
  • It was originally believed that one compound which had been isolated was responsible for all the many biological effects. The compound which has a chemical formula of C10H8O4 is known as scopoletin. Both noni and scopoletin are known to reduce blood pressure, have anti-inflammatory activity, exhibit antibiotic activity, antifungal activity and possess antitumour effects. Yet when researchers at the University of Hawaii tried to purify and isolate scopoletin from the rest of the noni extract, much of its activity was lost. In fact, both the biological effects and the serotonin receptor binding effects of the crude noni extract was lost upon purification of this presumed active ingredient. This leaves us the conclusion that other substances in noni must be present in order to produce its biological effects.
  • Noni has not been found to be harmful at any level, nor for any health condition.
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  • For more information about Tahitian Noni juice, Noni Skin and Hair Supplements, and Weight Loss Products including tapes and literature and research cited in this article, please contact Consumer Health or Alfina’s Place http://alfinas_place.bebioactive.com. 254-214-1165 Only those who are serious about they’re health and wellness Please. No blocked ID;s
  • More reading from Evelyn Teo http://foodscience.wikispaces.com/Noni

TO Be Continued

:Leave me some comments please.
Sara Kaftan Dress

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